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. 2010 Nov 24;132(46):16354-5.
doi: 10.1021/ja107738a. Epub 2010 Oct 28.

Enantioselective desymmetrization of cyclopropenes by hydroacylation

Diem H T Phan  1 , Kevin G M Kou, Vy M Dong
Affiliations

Enantioselective desymmetrization of cyclopropenes by hydroacylation

Diem H T Phan et al. J Am Chem Soc. .

Abstract

We report an enantioselective desymmetrization of cyclopropenes by intermolecular Rh-catalyzed hydroacylation. Cyclopropylketones, bearing quaternary stereocenters, are produced with diastereocontrol (up to >20:1) and excellent enantiomeric excess (up to >99 ee).

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