Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Nov 29;73(11):1756-62.
doi: 10.1021/np1002143. Epub 2010 Oct 28.

Camphoratins A-J, potent cytotoxic and anti-inflammatory triterpenoids from the fruiting body of Taiwanofungus camphoratus

Shwu-Jen Wu  1 , Yann-Lii Leu, Chou-Hsiung Chen, Chih-Hua Chao, De-Yang Shen, Hsiu-Hui Chan, E-Jian Lee, Tian-Shung Wu, Yea-Hwey Wang, Yuh-Chiang Shen, Keduo Qian, Kenneth F Bastow, Kuo-Hsiung Lee
Affiliations

Camphoratins A-J, potent cytotoxic and anti-inflammatory triterpenoids from the fruiting body of Taiwanofungus camphoratus

Shwu-Jen Wu et al. J Nat Prod. .

Abstract

Ten new triterpenoids, camphoratins A-J (1-10), along with 12 known compounds were isolated from the fruiting body of Taiwanofungus camphoratus. Their structures were established by spectroscopic analysis and chemical methods. Compound 10 is the first example of a naturally occurring ergosteroid with an unusual cis-C/D ring junction. Compounds 2-6 and 11 showed moderate to potent cytotoxicity, with EC(50) values ranging from 0.3 to 3 μM against KB and KB-VIN human cancer cell lines. Compounds 6, 10, 11, 14-16, 18, and 21 exhibited anti-inflammatory NO-production inhibition activity with IC(50) values of less than 5 μM, and were more potent than the nonspecific NOS inhibitor N(ω)-nitro-L-arginine methyl ester.

PubMed Disclaimer

References

    1. Wu SH, Yu ZH, Dai YC, Chen CT, Su CH, Chen LC, Hsu WC, Hwang GY. Fung Sci. 2004;19:109–116.
    1. Tsai ZT, Liaw SL. The Use and the Effect of Ganoderma. Sang-Yun Press; Taichung, Taiwan: 1982. p. 116.
    1. Shen YC, Wang YH, Chou YC, Chen CF, Lin LC, Chang TT, Tien JH, Chou CJ. Planta Med. 2004;70:310–314. - PubMed
    1. Chen CH, Yang SW, Shen YC. J Nat Prod. 1995;58:1655–1661. - PubMed
    1. Cherng IH, Chiang HC, Cheng MC, Wang Y. J Nat Prod. 1995;58:365–371.

Publication types

MeSH terms