Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Nov;16(11):1666-70.
doi: 10.3201/eid1611.101064.

Sulfadoxine/pyrimethamine intermittent preventive treatment for malaria during pregnancy

Philippe Deloron  1 , Gwladys Bertin, Valérie Briand, Achille Massougbodji, Michel Cot
Affiliations

Sulfadoxine/pyrimethamine intermittent preventive treatment for malaria during pregnancy

Philippe Deloron et al. Emerg Infect Dis. 2010 Nov.

Abstract

For monitoring efficacy of sulfadoxine/pyrimethamine intermittent preventive treatment for malaria during pregnancy, data obtained from studies of children seemed inadequate. High prevalence of triple and quadruple mutants in the dihydropteroate synthase and dihydrofolate reductase genes of Plasmodium falciparum parasites contrasts with the efficacy of sulfadoxine/pyrimethamine in reducing low birthweights and placental infection rates. In light of this discrepancy, emphasis on using molecular markers for monitoring efficacy of intermittent preventive treatment during pregnancy appears questionable. The World Health Organization recently proposed conducting in vivo studies in pregnant women to evaluate molecular markers for detecting resistance precociously. Other possible alternative strategies are considered.

PubMed Disclaimer

References

    1. Cot M, Deloron P. Malaria prevention strategies. Br Med Bull. 2003;67:137–48. 10.1093/bmb/ldg003 - DOI - PubMed
    1. Desai M, ter Kuile FO, Nosten F, McGready R, Asamoa K, Brabin B, et al. Epidemiology and burden of malaria in pregnancy. Lancet Infect Dis. 2007;7:93–104. 10.1016/S1473-3099(07)70021-X - DOI - PubMed
    1. World Health Organization. WHO Expert Committee on Malaria. Twentieth report. World Health Organ Tech Rep Ser. 2000;892:1–74. - PubMed
    1. Shulman CE, Dorman EK, Cutts F, Kawuondo K, Bulmer JN, Peshu N, et al. Intermittent sulphadoxine-pyrimethamine to prevent severe anaemia secondary to malaria in pregnancy: a randomised placebo-controlled trial. Lancet. 1999;353:632–6. 10.1016/S0140-6736(98)07318-8 - DOI - PubMed
    1. ter Kuile FO, van Eijk AM, Filler SJ. Effect of sulfadoxine/pyrimethamine resistance on the efficacy of intermittent preventive therapy for malaria control during pregnancy: a systematic review. JAMA. 2007;297:2603–16. 10.1001/jama.297.23.2603 - DOI - PubMed

Publication types

MeSH terms

LinkOut - more resources