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. 2010 Nov;16(11):1748-50.
doi: 10.3201/eid1611.100361.

Reassortment of ancient neuraminidase and recent hemagglutinin in pandemic (H1N1) 2009 virus

Priyasma Bhoumik  1 , Austin L Hughes
Affiliations

Reassortment of ancient neuraminidase and recent hemagglutinin in pandemic (H1N1) 2009 virus

Priyasma Bhoumik et al. Emerg Infect Dis. 2010 Nov.

Erratum in

  • Emerg Infect Dis. 2011 Nov;17(11):2180

Abstract

Sequence analyses show that the outbreak of pandemic (H1N1) 2009 resulted from the spread of a recently derived hemagglutinin through a population of ancient and more diverse neuraminidase segments. This pattern implies reassortment and suggests that the novel form of hemagglutinin conferred a selective advantage.

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Figures

Figure
Figure
Structure of the pandemic (H1N1) 2009 virus hemagglutinin homotrimer, indicating (in red) the 9 aa positions in hemagglutinin at which a residue not found in pre-2009 influenza (H1N1) was fixed (100% frequency) in pandemic (H1N1) 2009 virus.
See this image and copyright information in PMC

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