A Flt3L encounter: mTOR signaling in dendritic cells
- PMID: 21029968
- DOI: 10.1016/j.immuni.2010.10.001
A Flt3L encounter: mTOR signaling in dendritic cells
Abstract
The signaling pathway of the cytokine Flt3L in dendritic cells (DCs) is poorly defined. In this issue of Immunity, Sathaliyawala et al. (2010) report that the kinase mTOR functions as a mediator of Flt3L signaling in the development and homeostasis of DCs, particularly of the CD8(+) and CD103(+) DCs.
Copyright © 2010 Elsevier Inc. All rights reserved.
Comment on
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Mammalian target of rapamycin controls dendritic cell development downstream of Flt3 ligand signaling.Immunity. 2010 Oct 29;33(4):597-606. doi: 10.1016/j.immuni.2010.09.012. Epub 2010 Oct 7. Immunity. 2010. PMID: 20933441 Free PMC article.
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