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Clinical Trial
. 2010 Oct 30:2:31.
doi: 10.1186/1758-3284-2-31.

Sentinel lymph node mapping by indocyanin green fluorescence imaging in oropharyngeal cancer - preliminary experience

Marius G Bredell  1
Affiliations
Clinical Trial

Sentinel lymph node mapping by indocyanin green fluorescence imaging in oropharyngeal cancer - preliminary experience

Marius G Bredell. Head Neck Oncol. .

Abstract

Background: Sentinel lymph node (SLN) detection and biopsy is gaining popularity in the treatment of Head and Neck cancer. Various methods in this regard have been described, each with their respective advantages and disadvantages. The aim of this paper was to evaluate the potential application of Indocyanin Green (ICG) in the mapping and detection of sentinel lymph nodes (SLN) in cancers of the head and neck.

Methods: Patients with oropharyngeal cancer and N0 neck who were scheduled for primary tumor ablation as well as a neck dissection were selected. One milliliter of Indocyanin green was injected around the tumor and the sentinel node detection was performed by aiming the infra red video camera on the cervical area. When no detection was possible transcutaneously, a cervical incision was made, a sub-platysmal flap raised and further detection was done to visualize the fluorescing lymph nodes.

Results: Detection of cervical SLN was only possible when 5 mm or less tissue covered the sentinel lymph node. Accurate and clear detection of the lymph drainage pattern and SLN was possible. There is some uptake in other tissues such as the submandibular gland which is easily distinguishable from lymphatic tissue.

Conclusion: Indocyanin green fluorescence is a potential valuable potential tool in the detection of SLN in patients with oropharyngeal cancer which warrants further investigation.

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Figures

Figure 1
Figure 1
Molecular structure of Indocyanin green.
Figure 2
Figure 2
Infra red camera system.
Figure 3
Figure 3
Anatomical sites involved.
Figure 4
Figure 4
Level IB.
Figure 5
Figure 5
Jugulodigastric lymph nodes with fluorescence.
Figure 6
Figure 6
Lymph drainage around the submandibular gland.
See this image and copyright information in PMC

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