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Review
. 1990 Aug;1(4):257-63.

Cellular and viral ligands that interact with the EGF receptor

G J Todaro  1 , T M Rose, C E Spooner, M Shoyab, G D Plowman
Affiliations
  • PMID: 2103500
Review

Cellular and viral ligands that interact with the EGF receptor

G J Todaro et al. Semin Cancer Biol. 1990 Aug.

Abstract

The growth regulatory functions of a family of structurally related polypeptides are mediated through the membrane-bound epidermal growth factor receptor molecule. This ligand family includes epidermal growth factor, transforming growth factor-alpha, amphiregulin, and polypeptides encoded by several poxviruses. The structural and functional properties that are characteristic of the ligand family provide a basis for possible evolutionary relationships among the various ligands.

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