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Comment
. 2010 Nov 3;12(5):425-6.
doi: 10.1016/j.cmet.2010.10.007.

Megarole for microRNA in muscle disease

Colin G Crist  1 , Margaret Buckingham
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Free article
Comment

Megarole for microRNA in muscle disease

Colin G Crist et al. Cell Metab. .
Free article

Abstract

Deregulation of microRNAs in dystrophic muscle highlights their importance in muscle homeostasis. A recent study in Cell Metabolism (Cacchiarelli et al., 2010) shows that the presence of functional dystrophin is required for NO-dependent nitrosylation of the HDAC2 repressor and subsequent activation of a group of microRNAs required for muscle function.

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