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Comment
. 2010 Nov 3;12(5):427-8.
doi: 10.1016/j.cmet.2010.10.002.

IL-1β activation as a response to metabolic disturbances

Marc Y Donath  1 , Marianne Böni-Schnetzler
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Free article
Comment

IL-1β activation as a response to metabolic disturbances

Marc Y Donath et al. Cell Metab. .
Free article

Abstract

IL-1β is a major regulator of islet inflammation in type 2 diabetes. Several factors contribute to the induction of islet-derived IL-1β, including glucose, free fatty acids, and leptin. A recent report in Nature Immunology (Masters et al., 2010) identifies amyloid polypeptide as an additional enhancer of IL-1β production.

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