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Comment
. 2010 Nov 3;12(5):428-30.
doi: 10.1016/j.cmet.2010.10.008.

Allosteric trumps covalent in the control of glycogen synthesis

Matthew J Brady  1
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Allosteric trumps covalent in the control of glycogen synthesis

Matthew J Brady. Cell Metab. .
Free article

Abstract

Glycogen metabolism serves as a critical regulator of energy storage and maintenance of blood glucose levels in a physiological range. In this issue of Cell Metabolism, Bouskila et al. (2010) unexpectedly find that skeletal muscle glycogen accumulation is principally controlled by the allosteric activation of glycogen synthase, opening new avenues for investigation.

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