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Comment
. 2010 Nov 1;588(Pt 21):4063-4.
doi: 10.1113/jphysiol.2010.199521.

Water cotransport in pigmented epithelial cells

Richard Naftalin  1
Affiliations
Comment

Water cotransport in pigmented epithelial cells

Richard Naftalin. J Physiol. .
No abstract available

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Figures

Figure 1
Figure 1
Diagram showing how transport of NaCl into an internal cavity within NKCC1 within a transporter spanning channel will raise the osmolarity of channel content and lead to osmotic flow of water across the narrow channel to the external solution and mass flow of water and salts from the cavity to the cytosol
Figure 2
Figure 2. Model of fluid secretion incorporating water cotransport via NKCC1
Coupled flows of ions and water across the basal membrane via NKCC1 avoids the necessity of raising cytosolic tonicity to generate fluid influx across the basal membrane following initiation of fluid and electrolyte secretion across the apical and absorption across the basal membranes. Otherwise a rise in cytosolic tonicity would retard fluid secretion by reducing water efflux across the apical membrane via AQP5.
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