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. 1990 Mar;7(3):120-2.

[Thyroid myopathy. Effect of treatment with thyroid hormones]

[Article in Spanish]
A del Palacio  1 , J L Trueba, A Cabello, E Gutiérrez, I Moya, C Fernández Miranda, E García Albea, J R Ricoy
Affiliations
  • PMID: 2103764

[Thyroid myopathy. Effect of treatment with thyroid hormones]

[Article in Spanish]
A del Palacio et al. An Med Interna. 1990 Mar.

Abstract

We studied 20 patients afflicted with primary hypothyroidism and treated with thyroid hormone replacements, with the aim of evaluating the clinical, biochemical, EMG and anatomo-pathological effects. Cramps, as well as subjective and objective proximal muscular weakness, disappeared. Seric CPK was normalized in all cases after 1-8 weeks of treatment. EMG myopathic patterns faded away in all cases. Anatomopathological changes took longer to observe; 5 cases with new biopsy showed an isolate atrophy of type II fibers, one of them after 18 months in treatment; type I fibers had mitochondrial accumula without change compared to the initial biopsy. There was a clear tendency for the destroyed fibers to become normalized and for the structures similar to the "core" to vanish.

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Comment in

  • [Hypothyroid myopathy].
    López-Alburquerque T. López-Alburquerque T. An Med Interna. 1990 Mar;7(3):113-4. An Med Interna. 1990. PMID: 2103762 Spanish. No abstract available.

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