doi: 10.1039/c0cc02416c.
Epub 2010 Nov 1.
Direct and efficient N-heterocyclic carbene-catalyzed hydroxymethylation of aldehydes
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- PMID: 21038072
- DOI: 10.1039/c0cc02416c
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Direct and efficient N-heterocyclic carbene-catalyzed hydroxymethylation of aldehydes
Chem Commun (Camb).
.
Abstract
The N-heterocyclic carbene-catalyzed coupling of several aldehydes with paraformaldehyde is reported, directly providing the corresponding valuable hydroxymethyl ketones. Results of first mechanistic experiments for this remarkably selective transformation are also provided.
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