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. 2010 Dec 3;12(23):5426-9.
doi: 10.1021/ol1022596. Epub 2010 Nov 1.

Rh(III)-catalyzed oxidative coupling of N-aryl-2-aminopyridine with alkynes and alkenes

Jinlei Chen  1 , Guoyong Song, Cheng-Ling Pan, Xingwei Li
Affiliations

Rh(III)-catalyzed oxidative coupling of N-aryl-2-aminopyridine with alkynes and alkenes

Jinlei Chen et al. Org Lett. .

Abstract

[RhCp*Cl(2)](2) (1-2 mol %) can catalyze the oxidative coupling of N-aryl-2-aminopyridines with alkynes and arylates to give N-(2-pyridyl)indoles and N-(2-pyridyl)quinolones, respectively, using Cu(OAc)(2) as an oxidant. Coupling with styrenes gave mono- and/or disubstituted olefination products.

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