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. 1978 Aug 24;274(5673):756-61.
doi: 10.1038/274756a0.

Epidemiological evidence for causal relationship between Epstein-Barr virus and Burkitt's lymphoma from Ugandan prospective study

G de-Thé, A Geser, N E Day, P M Tukei, E H Williams, D P Beri, P G Smith, A G Dean, G W Bronkamm, P Feorino, W Henle

Epidemiological evidence for causal relationship between Epstein-Barr virus and Burkitt's lymphoma from Ugandan prospective study

G de-Thé et al. Nature. .

Abstract

Results from a prospective sero-epidemiological study initiated in Uganda in 1971 indicate that children with high antibody titres to Epstein-Barr virus structural antigens are at high risk of developing Burkitt's lymphoma. These findings strongly support a causal relationship between the Epstein-Barr virus and Burkitt's lymphoma but suggest that the oncogenic potential of the virus is realised only in exceptional circumstances.

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