Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Dec;131(4):459-65.
doi: 10.1111/j.1365-2567.2010.03362.x. Epub 2010 Oct 13.

T-cell autoantigens in the non-obese diabetic mouse model of autoimmune diabetes

Jeffrey Babad  1 , Ari Geliebter, Teresa P DiLorenzo
Affiliations
Review

T-cell autoantigens in the non-obese diabetic mouse model of autoimmune diabetes

Jeffrey Babad et al. Immunology. 2010 Dec.

Abstract

The non-obese diabetic (NOD) mouse model of autoimmune (type 1) diabetes has contributed greatly to our understanding of disease pathogenesis and has facilitated the development and testing of therapeutic strategies to combat the disease. Although the model is a valuable immunological tool in its own right, it reaches its fullest potential in areas where its findings translate to the human disease. Perhaps the foremost example of this is the field of T-cell antigen discovery, from which diverse benefits can be derived, including the development of antigen-specific disease interventions. The majority of NOD T-cell antigens are also targets of T-cell autoimmunity in patients with type 1 diabetes, and several of these are currently being evaluated in clinical trials. Here we review the journeys of these antigens from bench to bedside. We also discuss several recently identified NOD T-cell autoantigens whose translational potential warrants further investigation.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Sequence comparison of human and mouse heat-shock protein 60 (Hsp60) p277, DiaPep277, and the related peptide from Mycobacterium tuberculosis Hsp65. Dashes indicate identity to human p277, which corresponds to amino acids 437–460 of Hsp60. DiaPep277 is the version of human Hsp60 p277 that is used in clinical trials.
Figure 2
Figure 2
T-cell antigen delivery methods employed in non-obese diabetic (NOD) mice. In addition to the administration of free proteins or peptides, a variety of other antigen delivery strategies have been utilized in NOD mice. These are illustrated schematically and are not drawn to scale. See text for referenced examples of each delivery strategy.
See this image and copyright information in PMC

References

    1. Anderson MS, Bluestone JA. The NOD mouse: a model of immune dysregulation. Annu Rev Immunol. 2005;23:447–85. - PubMed
    1. Ikegami H, Makino S, Harada M, Eisenbarth GS, Hattori M. The cataract Shionogi mouse, a sister strain of the non-obese diabetic mouse: similar class II but different class I gene products. Diabetologia. 1988;31:254–8. - PubMed
    1. Makino S, Kunimoto K, Muraoka Y, Mizushima Y, Katagiri K, Tochino Y. Breeding of a non-obese, diabetic strain of mice. Exp Anim. 1980;29:1–13. - PubMed
    1. Driver JP, Serreze DV, Chen YG. Mouse models for the study of autoimmune type 1 diabetes: an NOD to similarities and differences to human disease. Semin Immunopathol. (in press) - PubMed
    1. Chaparro RJ, DiLorenzo TP. An update on the use of NOD mice to study autoimmune (type 1) diabetes. Expert Rev Clin Immunol. (in press) - PMC - PubMed

Publication types