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. 2011 Jun;48(6):808-12.
doi: 10.1111/j.1469-8986.2010.01141.x. Epub 2010 Oct 29.

Habituation in neural processing and subjective perception of respiratory sensations

Andreas von Leupoldt  1 , Andrea Vovk, Margaret M Bradley, Peter J Lang, Paul W Davenport
Affiliations

Habituation in neural processing and subjective perception of respiratory sensations

Andreas von Leupoldt et al. Psychophysiology. 2011 Jun.

Abstract

Reduced perception of respiratory sensations is associated with negative treatment outcome in asthma. We examined whether habituation in the neural processing of repeatedly experienced respiratory sensations may underlie subjective reports of reduced respiratory perception. Respiratory-related evoked potentials (RREP) elicited by inspiratory occlusions and reports of respiratory perception were compared between early and late experimental periods in healthy subjects. Reports of respiratory perception were reduced during late, compared to early, experimental periods. This was paralleled by reduced magnitudes in RREP components N1, P2, and P3 in late, compared to early, experimental periods. Habituation in the neural processing of respiratory sensations is a potential mechanism that underlies subjective reports of reduced respiratory perception and might represent a risk factor for reduced perception of respiratory sensations in asthma.

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Figures

Figure 1
Figure 1
Group means for the respiratory-related evoked potential (upper panel) and related scalp topographies at their peak latencies (lower panel) at frontal and centro-parietal regions for the first and the second halves of the experiment.
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