Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Nov;70(5):664-73.
doi: 10.1111/j.1365-2125.2010.03742.x.

Atenolol blunts blood pressure increase during dynamic resistance exercise in hypertensives

Ricardo S Gomides  1 , Luiz A R Costa, Dinoélia R Souza, Andréia C C Queiroz, João R C Fernandes, Kátia C Ortega, Décio Mion Junior, Taís Tinucci, Cláudia L M Forjaz
Affiliations

Atenolol blunts blood pressure increase during dynamic resistance exercise in hypertensives

Ricardo S Gomides et al. Br J Clin Pharmacol. 2010 Nov.

Abstract

Aims: This study was conducted to determine whether atenolol was able to decrease BP level and mitigate BP increase during dynamic resistance exercise performed at three different intensities in hypertensives.

Methods: Ten essential hypertensives (systolic/diastolic BP between 140/90 and 160/105mmHg) were blindly studied after 6 weeks of placebo and atenolol. In each phase, volunteers executed, in a random order, three protocols of knee-extension exercises to fatigue: (i) one set at 100% of 1RM; (ii) three sets at 80% of 1RM; and (iii) three sets at 40% of 1RM. Intra-arterial radial blood pressure was measured throughout the protocols.

Results: Atenolol decreased systolic BP maximum values achieved during the three exercise protocols (100% = 186 ± 4 vs. 215 ± 7, 80% = 224 ± 7 vs. 247 ± 9 and 40% = 223 ± 7 vs. 252 ± 16mmHg, P < 0.05). Atenolol also mitigated an increase in systolic BP in the first set of exercises (100% =+38 ± 5 vs.+54 ± 9; 80% =+68 ± 11 vs. +84 ± 13 and 40% =+69 ± 7 vs.+84 ± 14, mmHg, P < 0.05). Atenolol decreased diastolic BP values and mitigated its increase during exercise performed at 100% of 1RM (126 ± 6 vs. 145 ± 6 and +41 ± 6 vs.+52 ± 6, mmHg, P < 0.05), but not at the other exercise intensities.

Conclusions: Atenolol was effective in both reducing systolic BP maximum values and mitigating BP increase during resistance exercise performed at different intensities in hypertensive subjects.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Systolic blood pressure measured for each heartbeat in one hypertensive patient receiving placebo (solid line with solid circles) and atenolol (dotted line with open circles). Measurements were made before and during the first set of knee-extension exercises performed to failure at 80% of 1 RM
Figure 2
Figure 2
Systolic blood pressure absolute values (SBP) and changes (ΔSBP exercise – pre-exercise) measured pre-exercise (PRE) and during three sets (S1, S2, and S3) and intervals (I1, I2, and I3) of knee-extension resistance exercise performed to failure at 100% (panels A and B), 80% (panels C and D), and 40% (panels E and F) of 1 RM. Measures were taken with subjects receiving placebo (solid line with solid circles or black bars) and atenolol (dotted line with open circles or white bars) in hypertensive subjects. * Significantly different from placebo (P < 0.05). # Significantly different from PRE (P < 0.05). $ Significantly different from S1 (P < 0.05). Data = mean ± SE
Figure 3
Figure 3
Diastolic blood pressure absolute values (DBP) and changes (ΔDBP exercise – pre-exercise) measured pre-exercise (PRE) and during three sets (S1, S2, and S3) and intervals (I1, I2, and I3) of knee-extension resistance exercise performed to failure at 100% (panels A and B), 80% (panels C and D), and 40% (panels E and F) of 1 RM. Measurements were taken with subjects receiving placebo (solid line with solid circles or black bars) and atenolol (dotted line with open circles or white bars) in hypertensive subjects. * Significantly different from placebo (P < 0.05). # Significantly different from PRE (P < 0.05). () Main effect significance in anova. Data = mean ± SE
Figure 4
Figure 4
Heart rate absolute values (HR) and changes (ΔHR exercise – pre-exercise) measured pre-exercise (PRE) and during three sets (S1, S2, and S3) and intervals (I1, I2, and I3) of knee-extension resistance exercise performed to failure at 100% (panels A and B), 80% (panels C and D), and 40% (panels E and F) of 1 RM. Measurements were taken with subjects receiving placebo (solid line with solid circles or black bars) and atenolol (dotted line with open circles or white bars) in hypertensive subjects. * Significantly different from placebo (P < 0.05). # Significantly different from PRE (P < 0.05). () Main effect significance in anova. Data = mean ± SE
See this image and copyright information in PMC

References

    1. Fleck SJ, Kraemer WJ. Basic principles of resistance training and exercise prescription. In: Fleck SJ, Kraemer WJ, editors. Designing Resistance Training Programs. 3rd. Champaign, IL: Human Kinetics; 2004. pp. 3–12.
    1. Pescatello LS, Franklin BA, Fagard R, Farquhar WB, Kelley GA, Ray CA. American colle-ge of sports medicine position stand. Exercise and hypertension. Med Sci Sports Exerc. 2004;36:533–53. - PubMed
    1. Bezucha GR, Lenser MC, Hanson PG, Nagle FJ. Comparison of hemodynamic responses to static and dynamic exercise. J Appl Physiol. 1982;53:1589–93. - PubMed
    1. Harris KA, Holly RG. Physiological response to circuit weight training in borderline hypertensive subjects. Med Sci Sports Exerc. 1987;19:246–52. - PubMed
    1. Haslam DRS, McCartney N, McKelvie RS, MacDougall JD. Direct measurements of arterial blood pressure during formal weightlifting in cardiac patients. J Cardiopulm Rehabil. 1988;8:213–25.

Publication types