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. 2010 Nov;70(5):749-55.
doi: 10.1111/j.1365-2125.2010.03751.x.

Emergency re-admissions to hospital due to adverse drug reactions within 1 year of the index admission

Emma C Davies  1 , Christopher F Green, David R Mottram, Philip H Rowe, Munir Pirmohamed
Affiliations

Emergency re-admissions to hospital due to adverse drug reactions within 1 year of the index admission

Emma C Davies et al. Br J Clin Pharmacol. 2010 Nov.

Abstract

Aim: The proportion of re-admissions to hospital caused by ADRs is poorly documented in the UK. The aim of this study was to evaluate the impact of ADRs on re-admission to hospital after a period as an inpatient.

Methods: One thousand patients consecutively admitted to 12 wards were included. All subsequent admissions for this cohort within 1 year of discharge from the index admission were retrospectively reviewed.

Results: Of the 1000 patients included, 403 (40.3%, 95% CI 39.1, 45.4%) were re-admitted within 1 year. Complete data were available for 290 (70.2%) re-admitted patients, with an ADR contributing to admission in 60 (20.8%, 95% CI 16.4, 25.6%) patients. Presence of an ADR in the index admission did not predict for an ADR-related re-admission (10.5% vs. 7.2%, P=0.25), or re-admission overall (47.2% vs. 41.2%, P=0.15). The implicated drug was commenced in the index admission in 33/148 (22.3%) instances, with 37/148 (25%) commenced elsewhere since the index admission. Increasing age and an index admission in a medical ward were associated with a higher incidence of re-admission ADR. The most frequent causative drugs were anti-platelets and loop diuretics, with bleeding and renal impairment the most frequent ADRs. Over half (52/91, 57.1%) of the ADRs were judged to be definitely or possibly avoidable.

Conclusions: One fifth of patients re-admitted to hospital within 1 year of discharge from their index admission are re-admitted due to an ADR. Our data highlight drug and patient groups where interventions are needed to reduce the incidence of ADRs leading to re-admission.

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Figures

Figure 1
Figure 1
Flow chart showing numbers of patients with ADRs during index admission and those re-admitted within 1 year of discharge from index admission
See this image and copyright information in PMC

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References

    1. Pirmohamed M, James S, Meakin S, Green C, Scott AK, Walley TJ, Farrar K, Park K, Breckenridge AM. Adverse drug reactions as a cause of admission to hospital: prospective analysis of 18 820 patients. BMJ. 2004;329:15–9. - PMC - PubMed
    1. Davies EC, Green CF, Taylor S, Williamson P, Mottram DR, Pirmohamed M. Adverse drug reactions in hospital in-patients: a prospective analysis of 3695 patient-episodes. PLoS ONE. 2009;4:e4439. doi: 10.1371/journal.pone.0004439. - DOI - PMC - PubMed
    1. Chapman J. 500 000 Hospital patients sent home too soon every year. Available at http://www.dailymail.co.uk/news/article-1247568/500-000-hospital-patient... (last accessed 12 February 2010.
    1. Dormann H, Neubert A, Criegee-Rieck M, Egger T, Radespeiel-Troger M, Azaz-Livshits T, Levy M, Brune K, Hahn EG. Readmissions and adverse drug reactions in internal medicine: the economic impact. Ann Intern Med. 2004;255:653–63. - PubMed
    1. Zhang M, Holman DJ, Preen DB, Brameld K. Repeat adverse drug reactions causing hospitalization in older Australians: a population-based longitudinal study 1980–2003. Br J Clin Pharmacol. 2007;63:163–70. - PMC - PubMed