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. 1978 Jul;303(3):295-7.
doi: 10.1007/BF00498057.

High affinity of carozolol for beta-adrenoceptors coupled to the adenylyl cyclase in ventricular myocardium of kitten and Xenopus laevis

T H Morris, L Birnbaumer, A J Kaumann

High affinity of carozolol for beta-adrenoceptors coupled to the adenylyl cyclase in ventricular myocardium of kitten and Xenopus laevis

T H Morris et al. Naunyn Schmiedebergs Arch Pharmacol. 1978 Jul.

Abstract

Catecholamine-induced stimulation of adenylyl cyclase in ventricular membranes of kitten and Xenopus laevis was antagonized competitively by carazolol. Apparent equilibrium constants ranging between 100-170 pM were estimated for the beta-adrenoceptor-carazolol complex.

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