Vagrant stem cells draft their gene companions
- PMID: 21040892
- PMCID: PMC3006234
- DOI: 10.1016/j.stem.2010.10.006
Vagrant stem cells draft their gene companions
Abstract
In a recent issue of Nature Medicine, Ryan et al. (2010) uncover genetic modifiers of G-CSF responses by hematopoietic progenitors. The authors document a negative role of EGFR signaling and, provided an analogous pathway functions in humans, propose a potential new angle to promote clinical blood stem cell mobilization.
Copyright © 2010 Elsevier Inc. All rights reserved.
Comment on
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Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization.Nat Med. 2010 Oct;16(10):1141-6. doi: 10.1038/nm.2217. Epub 2010 Sep 26. Nat Med. 2010. PMID: 20871610 Free PMC article.
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