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. 2010 Nov-Dec;46(6):413-7.
doi: 10.5326/0460413.

Treatment of feline gastrointestinal small-cell lymphoma with chlorambucil and glucocorticoids

Timothy J Stein  1 , Mackenzie Pellin, Howard Steinberg, Ruthanne Chun
Affiliations

Treatment of feline gastrointestinal small-cell lymphoma with chlorambucil and glucocorticoids

Timothy J Stein et al. J Am Anim Hosp Assoc. 2010 Nov-Dec.

Abstract

Gastrointestinal (GI) lymphoma is the most frequently diagnosed form of lymphoma in the cat and is categorized into two distinct forms based on the size of neoplastic lymphocytes. Treatments for both large- and small-cell GI lymphoma have been described previously; however, multiple chemotherapy protocols were used, a minimal amount of histopathological characterization was provided, and, in most studies, the majority of diagnoses were obtained via endoscopic pinch biopsies. Twenty-eight cats (24 with full-thickness intestinal biopsies) were diagnosed with small-cell GI lymphoma and treated with a combination of chlorambucil and glucocorticoids. The majority of cases were strongly CD3+, and many displayed epitheliotropism. The overall clinical response rate was 96%, with a median clinical remission duration of 786 days. Follow-up identified seven cats with relapsed disease-all of which were treated with a rescue protocol of cyclophosphamide and glucocorticoids; the response rate was 100%, and four of the 28 cats were diagnosed with a second malignancy.

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Figures

Figure 1
Figure 1
Overall duration of first remission for cats with GI small-cell lymphoma treated with chlorambucil and glucocorticoids.
See this image and copyright information in PMC

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