Drug interaction and pharmacist
- PMID: 21042495
- PMCID: PMC2964764
- DOI: 10.4103/0975-1483.66807
Drug interaction and pharmacist
Abstract
The topic of drug-drug interactions has received a great deal of recent attention from the regulatory, scientific, and health care communities worldwide. Nonsteroidal anti-inflammatory drugs, antibiotics and, in particular, rifampin are common precipitant drugs prescribed in primary care practice. Drugs with a narrow therapeutic range or low therapeutic index are more likely to be the objects for serious drug interactions. Object drugs in common use include warfarin, fluoroquinolones, antiepileptic drugs, oral contraceptives, cisapride, and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. The pharmacist, along with the prescriber has a duty to ensure that patients are aware of the risk of side effects and a suitable course of action should they occur. With their detailed knowledge of medicine, pharmacists have the ability to relate unexpected symptoms experienced by patients to possible adverse effects of their drug therapy.
Keywords: Computerized screening systems; current indian scenario of drug interactions; drug interaction management; drug interactions.
Conflict of interest statement
References
-
- Farkas D, Shader RI, von Moltke LL, Greenblatt DJ. Mechanisms and consequences of drug-drug interactions. In: Gad SC, editor. Preclinical Development Handbook: ADME and Biopharmaceutical Properties. Philadelphia: Wiley; 2008. pp. 879–917.
-
- Ament PW, Bertolino JG, Liszewski JL. Clinically significant drug interactions. Am Fam Physician. 2000;61:1745–54. - PubMed
-
- Montané E, Barriocanal A, Isern I, Parajon T, Costa J. Multiple drug interactions-induced serotonin syndrome: A case report. J Clin Pharm Ther. 2009;34:485–7. - PubMed
-
- MedWatch-What Is A Serious Adverse Event? Available from: http://www.fda.gov/medwatch/report/DESK/advevnt.htm [last retrieved on 2007 Sep 18]
-
- Clinical Drug Use. Available from: http://www.clinicaldruguse.com/ [last retrieved on 2007 Sep 18]
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