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Review
. 2010 Sep-Oct;28(5 Suppl 61):S95-101.
Epub 2010 Oct 28.

Side effects and management of side effects of methotrexate in rheumatoid arthritis

K Albrecht  1 , U Müller-Ladner
Affiliations
  • PMID: 21044440
Review

Side effects and management of side effects of methotrexate in rheumatoid arthritis

K Albrecht et al. Clin Exp Rheumatol. 2010 Sep-Oct.

Abstract

Low-dose methotrexate (MTX) remains the first-line treatment option among the disease-modifying antirheumatic drugs in patients with rheumatoid arthritis. However, diverse side effects are the major reason for MTX withdrawal and change of treatment. The following article reviews the published data on general and organ-specific side effects and outlines the current recommendations addressing prevention and management of MTX-associated adverse effects.

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