Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2010 Sep;30(5):439-42.
doi: 10.1016/j.semnephrol.2010.07.001.

Integrative biology of renal disease: toward a holistic understanding of the kidney's function and failure

Matthias Kretzler  1 , Clemens D Cohen
Affiliations
Editorial

Integrative biology of renal disease: toward a holistic understanding of the kidney's function and failure

Matthias Kretzler et al. Semin Nephrol. 2010 Sep.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Multidimensional integration of large-scale data sets along the Genome – Phenome continuum integrating systems biology and patho- physiology
Fig. 2
Fig. 2. Structure and capabilities of Nephromine
The Nephromine database consists of three layers: data input, data analysis, and data visualization. The data input layer has two components, the microarray data pipeline and the annotation data warehouse. The microarray pipeline is used internally to identify and prioritize microarray studies in the literature. The pipeline also draws data directly from the Stanford Microarray Database and the NCBI Gene Expression Omnibus. The data-analysis layer consists of sample facts standardization and automated statistical analysis. The sample facts standardization utilizes the NCI Thesaurus and manual annotation. The automated statistical analysis component is implemented in Perl and R. A series of scripts monitors the database for new data and sample parameters and automatically performs differential expression analysis, cluster analysis, and concept analysis, when needed. The Nephromine web servers query data from the Nephromine database and display tabular and graphical representations of the data and analysis results.
See this image and copyright information in PMC

References

    1. Sauer U. Genetics. Getting closer to the whole picture. Science. 2007;316:550–551. - PubMed
    1. Hodgin JB, Cohen CD. Experimental approaches to the human renal transcriptome. Sem Nephrol. 2010 - PubMed
    1. Mohtat D, Susztak K. Fine Tuning Gene Expression: The Epigenome. Sem Nephrol. 2010 - PMC - PubMed
    1. Velic A, Macek B, Wagner CA. Towards quantitative proteomics of organ substructures: implications for renal physiology. Sem Nephrol. 2010 - PubMed
    1. Wang JH, Byun J, Pennathur S. Analytical Approaches to Metabolomics and Applications to Systems Biology. Sem Nephrol. 2010 - PMC - PubMed

Publication types