Ensembl 2011

Abstract

The Ensembl project (http://www.ensembl.org) seeks to enable genomic science by providing high quality, integrated annotation on chordate and selected eukaryotic genomes within a consistent and accessible infrastructure. All supported species include comprehensive, evidence-based gene annotations and a selected set of genomes includes additional data focused on variation, comparative, evolutionary, functional and regulatory annotation. The most advanced resources are provided for key species including human, mouse, rat and zebrafish reflecting the popularity and importance of these species in biomedical research. As of Ensembl release 59 (August 2010), 56 species are supported of which 5 have been added in the past year. Since our previous report, we have substantially improved the presentation and integration of both data of disease relevance and the regulatory state of different cell types.

Figure 1.

A view of variants with high linkage disequilibrium to rs1333049 in the Tosconi (TSI) population including the phenotypes associated with these variants and colour-coded P-values representing the strength of these phenotype associations. Variants have been sorted by distance to the focus SNP using the arrows in the table header row.

Figure 2.

Core and other evidence regulatory features near the 5′-end of the RPS12 gene in the GM12878 cell line. A representation of the raw DNAse-seq and ChIP-seq signals are shown for both types of features in the multi-wiggle plot below the respective collection of significant hits. Peak centres are marked in each hit by a vertical bar.