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. 2011 Jan;39(Database issue):D991-6.
doi: 10.1093/nar/gkq1106. Epub 2010 Nov 2.

CADgene: a comprehensive database for coronary artery disease genes

Hui Liu  1 , Wei Liu, Yifang Liao, Long Cheng, Qian Liu, Xiang Ren, Lisong Shi, Xin Tu, Qing Kenneth Wang, An-Yuan Guo
Affiliations

CADgene: a comprehensive database for coronary artery disease genes

Hui Liu et al. Nucleic Acids Res. 2011 Jan.

Abstract

Coronary artery disease (CAD) is a complex, multifactorial disease and a leading cause of mortality world wide. Over the past decades, great efforts have been made to elucidate the underlying genetic basis of CAD and massive data have been accumulated. To integrate these data together and to provide a useful resource for researchers, we developed the CADgene, a comprehensive database for CAD genes. We manually extracted CAD-related evidence for more than 300 candidate genes for CAD from over 1300 publications of genetic studies. We classified these candidate genes into 12 functional categories based on their roles in CAD. For each gene, we extracted detailed information from related studies (e.g. the size of case-control, population, SNP, odds ratio, P-value, etc.) and made useful annotations, which include general gene information, Gene Ontology annotations, KEGG pathways, protein-protein interactions and others. Besides the statistical number of studies for each gene, CADgene also provides tools to search and show the most frequently studied candidate genes. In addition, CADgene provides cumulative data from 11 publications of CAD-related genome-wide association studies. CADgene has a user-friendly web interface with multiple browse and search functions. It is freely available at http://www.bioguo.org/CADgene/.

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Figures

Figure 1.
Figure 1.
Examples of the cascading browse and gene information in CADgene. (A) Functional categories in CADgene. (B) Gene list for the RAS functional category. (C) CAD-related studies for a specific gene (i.e. AGTR1). (D) GO and KEGG annotations. (E) PPI information in a table. (F) Graphic show of the PPI network. (G) Detailed information of a CAD-related study.
See this image and copyright information in PMC

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