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Comment
. 2010 Dec 1;16(23):5605-7.
doi: 10.1158/1078-0432.CCR-10-2502. Epub 2010 Nov 2.

Heading in a new direction: drug permeability in breast cancer brain metastasis

George W Sledge Jr  1
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Heading in a new direction: drug permeability in breast cancer brain metastasis

George W Sledge Jr. Clin Cancer Res. .

Abstract

Systemic therapies for breast cancer brain metastasis are largely unsuccessful. Mouse models of brain metastasis show significant heterogeneity in uptake of paclitaxel and doxorubicin, with average levels more than those seen in normal brain tissue, but significantly less than in metastases to other organs.

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