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Comment
. 2010 Nov;12(11):1026-8.
doi: 10.1038/ncb1110-1026.

Opening ahead: early steps in lumen formation revealed

Gerard Apodaca
Comment

Opening ahead: early steps in lumen formation revealed

Gerard Apodaca. Nat Cell Biol. 2010 Nov.

Abstract

The contribution and order of polarity complexes and vesicular trafficking events during lumen formation remains obscure. Now, lumenogenesis in MDCK cell cysts is shown to require a Rab11a-Rabin8-Rab8a network that recruits Sec15A and Cdc42 and that promotes apical exocytosis by enlisting the Par complex and Sec8-Sec10 to an early apical membrane initiation site.

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