doi: 10.1038/ncb1110-1029.
An age of fewer histones
- PMID: 21045802
- DOI: 10.1038/ncb1110-1029
Item in Clipboard
An age of fewer histones
Nat Cell Biol.
2010 Nov.
Abstract
Changes in chromatin structure are a conserved hallmark of ageing, and the mechanism driving these changes, as well as their functional significance, are heavily investigated. Loss of core histones is now observed in aged cells and may contribute to this phenomenon. Histone loss is coupled to cell division and seems to be triggered by telomeric DNA damage.
Similar articles
-
Evidence that Spt6p controls chromatin structure by a direct interaction with histones.Science. 1996 Jun 7;272(5267):1473-6. doi: 10.1126/science.272.5267.1473. Science. 1996. PMID: 8633238
-
Previously uncharacterized amino acid residues in histone H3 and H4 mutants with roles in DNA damage repair response and cellular aging.FEBS J. 2019 Mar;286(6):1154-1173. doi: 10.1111/febs.14723. Epub 2018 Dec 28. FEBS J. 2019. PMID: 30536627
-
Histone modifications for chromatin dynamics and cellular plasticity.J Mol Biol. 2017 Jun 30;429(13):1921-1923. doi: 10.1016/j.jmb.2017.06.001. J Mol Biol. 2017. PMID: 28623961 No abstract available.
-
Epigenetics of T cell aging.J Leukoc Biol. 2018 Oct;104(4):691-699. doi: 10.1002/JLB.1RI0418-160R. Epub 2018 Jun 27. J Leukoc Biol. 2018. PMID: 29947427 Free PMC article. Review.
-
Posttranslational modifications of repair factors and histones in the cellular response to stalled replication forks.DNA Repair (Amst). 2009 Sep 2;8(9):1089-100. doi: 10.1016/j.dnarep.2009.04.010. Epub 2009 May 30. DNA Repair (Amst). 2009. PMID: 19482523 Review.
Cited by
-
Chromatin dynamics in DNA double-strand break repair.Biochim Biophys Acta. 2012 Jul;1819(7):811-9. doi: 10.1016/j.bbagrm.2012.01.002. Epub 2012 Jan 17. Biochim Biophys Acta. 2012. PMID: 22285574 Free PMC article. Review.
-
SIRT6 Depletion Suppresses Tumor Growth by Promoting Cellular Senescence Induced by DNA Damage in HCC.PLoS One. 2016 Nov 8;11(11):e0165835. doi: 10.1371/journal.pone.0165835. eCollection 2016. PLoS One. 2016. PMID: 27824900 Free PMC article.
-
Sustained activation of Akt elicits mitochondrial dysfunction to block Plasmodium falciparum infection in the mosquito host.PLoS Pathog. 2013 Feb;9(2):e1003180. doi: 10.1371/journal.ppat.1003180. Epub 2013 Feb 28. PLoS Pathog. 2013. PMID: 23468624 Free PMC article.
-
Cellular response to moderate chromatin architectural defects promotes longevity.Sci Adv. 2019 Jul 10;5(7):eaav1165. doi: 10.1126/sciadv.aav1165. eCollection 2019 Jul. Sci Adv. 2019. PMID: 31309140 Free PMC article.
-
Ageing-associated changes in transcriptional elongation influence longevity.Nature. 2023 Apr;616(7958):814-821. doi: 10.1038/s41586-023-05922-y. Epub 2023 Apr 12. Nature. 2023. PMID: 37046086 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
