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. 1990 Jan;10(1):418-21.
doi: 10.1128/mcb.10.1.418-421.1990.

A gene that encodes a protein consisting solely of zinc finger domains is preferentially expressed in transformed mouse cells

M Ernoult-Lange  1 , M Kress, D Hamer
Affiliations

A gene that encodes a protein consisting solely of zinc finger domains is preferentially expressed in transformed mouse cells

M Ernoult-Lange et al. Mol Cell Biol. 1990 Jan.

Abstract

We describe the cloning and characterization of the mouse MOK-2 gene, a new member of the Krüppel family of zinc finger proteins. Sequencing of both cDNA and genomic clones showed that the predicted MOK-2 protein consists of seven zinc finger domains with only five additional amino acids. The finger domains of MOK-2 are highly homologous to one another but not to those of other zinc finger proteins. MOK-2 is preferentially expressed in transformed cell lines, brain tissue, and testis tissue. Its possible role in cellular transformation is discussed.

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