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. 2010 Dec 3;75(23):8330-2.
doi: 10.1021/jo1018798. Epub 2010 Nov 3.

A mild Negishi cross-coupling of 2-heterocyclic organozinc reagents and aryl chlorides

Michael R Luzung  1 , Jigar S Patel, Jingjun Yin
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A mild Negishi cross-coupling of 2-heterocyclic organozinc reagents and aryl chlorides

Michael R Luzung et al. J Org Chem. .

Abstract

A mild Negishi cross-coupling of 2-heterocyclic organozinc reagents and aryl chlorides is described. The use of Pd(2)(dba)(3) and X-Phos as a ligand provides high yields for many examples. An efficient method to generate the organozinc reagents at room temperature is also demonstrated.

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