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Editorial
. 2011 Jan;300(1):C6-8.
doi: 10.1152/ajpcell.00444.2010. Epub 2010 Nov 3.

Molecular determinants of renal glucose reabsorption. Focus on "Glucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2"

Volker Vallon
Editorial

Molecular determinants of renal glucose reabsorption. Focus on "Glucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2"

Volker Vallon. Am J Physiol Cell Physiol. 2011 Jan.
No abstract available

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Figures

Fig. 1.
Fig. 1.
Glucose transport in the kidney. Under normoglycemia, ∼97% of filtered glucose is reabsorbed via the Na+-glucose cotransporter SGLT2 primarily in the early segments of the proximal tubule. A significant capacity of SGLT1 to reabsorb glucose in later segments of the proximal tubule is unmasked by SGLT2 inhibition (∼40% of filtered glucose under normoglycemia; see numbers in parentheses), on the basis of our previous work (14) and the assumption that apical tubular glucose uptake in the kidney is primarily mediated by SGLT2 and SGLT1. The glucose transporters GLUT2 and GLUT1 mediate glucose transport across the basolateral membrane. Na+-glucose cotransport is electrogenic, and luminal K+ channels serve to stabilize the membrane potential (12, 13): KCNE1/unknown α-subunit and KCNE1/KCNQ1 in early and late proximal tubule, respectively.
See this image and copyright information in PMC

Comment on

References

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