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. 2010 Dec 29;21(18):1182-8.
doi: 10.1097/WNR.0b013e32834127eb.

Subgenual cingulate connectivity in children with a history of preschool-depression

Michael S Gaffrey  1 , Joan L Luby, Grega Repovš, Andy C Belden, Kelly N Botteron, Katherine R Luking, Deanna M Barch
Affiliations

Subgenual cingulate connectivity in children with a history of preschool-depression

Michael S Gaffrey et al. Neuroreport. .

Abstract

The subgenual anterior cingulate cortex (sgACC) presents altered functional connections with other regions of the brain in individuals with depression. However, the developmental nature of this phenomenon remains largely unexplored. Functional connections of the sgACC were examined in 36 school age children, 17 with a history of preschool onset major depressive disorder (PO-MDD). The sgACC exhibited increased connections with cognitive control regions in healthy children and increased connections with thalamic and parietal regions in the PO-MDD group. A significant correlation between dysregulated emotional behavior and connectivity of the sgACC and dorsal medial prefrontal cortex was also found. These findings demonstrate that atypical sgACC functional connections are evident as early as school age in children with a history of PO-MDD and suggest an association with a very early episode of depression.

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Figures

Figure 1
Figure 1
Functional connectivity maps for the right subgenual anterior cingulate seed in (A) Healthy (C) PO-MDD and (B) group differences. Images show regions significantly correlated with the subgenual anterior cingulate seed volume as well as group differences after correction for multiple comparisons (see text). In A and B warm and cool coolers indicate positive and negative connectivity respectively. In C cool coolers indicate increased connectivity in the Healthy group while warm colors indicate increased connectivity in the PO-MDD group.
Figure 2
Figure 2
Functional connectivity maps for the left subgenual anterior cingulate seed in (A) Healthy (C) PO-MDD and (B) group differences. Images show regions significantly correlated with the subgenual anterior cingulate seed volume as well as group differences after correction for multiple comparisons (see text). In A and B warm and cool coolers indicate positive and negative connectivity respectively. In C cool coolers indicate increased connectivity in the Healthy group while warm colors indicate increased connectivity in the PO-MDD group.
See this image and copyright information in PMC

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