Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Feb 10:2010:897602.
doi: 10.4061/2010/897602.

Thyroid Hormones Concentrations during the Mid-Dry Period: An Early Indicator of Fatty Liver in Holstein-Friesian Dairy Cows

Horea Samanc  1 , Velibor Stojić, Danijela Kirovski, Milijan Jovanović, Horia Cernescu, Ivan Vujanac
Affiliations

Thyroid Hormones Concentrations during the Mid-Dry Period: An Early Indicator of Fatty Liver in Holstein-Friesian Dairy Cows

Horea Samanc et al. J Thyroid Res. .

Abstract

Relationship between postpartal fatty liver and thyroid gland activity during the peripartal and mid dry periods was studied. Twenty one dry cows were chosen. Blood samples were obtained on days -30, -2, and +12 related to calving and analized for thyroxine (T(4)) and triiodothyronine (T(3)). A T(3)/T(4) ratio was calculated. Liver tissue samples were taken 12 d after calving and tested for the lipid content. Cows were divided into three groups: mild (<20% fat), moderate (20 to 30%), or severe fatty liver (>30%). Cows, that were affected with severe fatty liver, were hypothyroid prior to development of the condition due to lower T(4) concentrations, and had significantly lower concentration of T(3) and higher T(3)/T(4) ratios than cows with mild and moderate fatty liver. Thus, hypothyroid state during mid-dry period may be an early indicator of postpartal fatty liver and may provoke T(3)/T(4) ratio increase in this group of cows.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Serum levels (Mean  ± SD) of T4 in nmol/L (a), T3 in nmol/L (b) and T3/T4 ratio (c).
See this image and copyright information in PMC

References

    1. Goff JP, Horst RL. Physiological changes at parturition and their relationship to metabolic disorders. Journal of Dairy Science. 1997;80(7):1260–1268. - PubMed
    1. Mulligan FJ, Doherty ML. Production diseases of the transition cow. Veterinary Journal. 2008;176(1):3–9. - PubMed
    1. Stockdale CR. Body condition at calving and the performance of dairy cows in early lactation under Australian conditions: a review. Australian Journal of Experimental Agriculture. 2001;41(6):823–839.
    1. Hanigan MD, Reynolds CK, Humphries DJ, Lupoli B, Sutton JD. A model of net amino acid absorption and utilization by the portal-drained viscera of the lactating dairy cow. Journal of Dairy Science. 2004;87(12):4247–4268. - PubMed
    1. Bobe G, Young JW, Beitz DC. Invited review: pathology, etiology, prevention, and treatment of fatty liver in dairy cows. Journal of Dairy Science. 2004;87(10):3105–3124. - PubMed

LinkOut - more resources