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Review
. 2010 Nov;36(8):881-7.
doi: 10.1055/s-0030-1267042. Epub 2010 Nov 3.

Platelet- and megakaryocyte-derived microparticles

Robert Flaumenhaft  1 , Albert T A Mairuhu, Joseph E Italiano
Affiliations
Review

Platelet- and megakaryocyte-derived microparticles

Robert Flaumenhaft et al. Semin Thromb Hemost. 2010 Nov.

Abstract

Platelet microparticles are the most abundant cell-derived microparticle subtype in the circulation. Yet the mechanism by which platelet microparticles are formed is poorly defined. This review highlights the concept of the generation of microparticles from platelets and their precursor cells, megakaryocytes. Special emphasis is placed on the mechanisms of microparticle formation and novel functions for microparticles in normal physiology and disease states.

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