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Review
. 2010 Nov;36(8):925-9.
doi: 10.1055/s-0030-1267046. Epub 2010 Nov 3.

Microparticles and exosomes in gynecologic neoplasias

Rienk Nieuwland  1 , Joris A M van der Post, Christianne A R Lok, Gemma Kenter, Augueste Sturk
Affiliations
Review

Microparticles and exosomes in gynecologic neoplasias

Rienk Nieuwland et al. Semin Thromb Hemost. 2010 Nov.

Erratum in

  • Semin Thromb Hemost. 2011 Feb;37(1):95. Gemma, Christianne A R Lok [corrected to Lok, Christianne A R]; Kenter, G [corrected to Kenter, Gemma]

Abstract

This review presents an overview of the functions of microparticles and exosomes in gynecologic neoplasias. Growing evidence suggests that vesicles released from cancer cells in gynecologic malignancies contribute to the hypercoagulable state of these patients and contribute to tumor progression by suppressing the immune system, facilitating extracellular matrix degradation and removal of cytostatics from the tumor cell. Exosomes from ovarian carcinoma cells were shown to be present in peripheral blood and to augment tumor growth, suggesting that these vesicles directly support growth of tumor cells.

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