doi: 10.1126/science.210500.
Trisodium phosphonoformate, a new antiviral compound
- PMID: 210500
- DOI: 10.1126/science.210500
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Trisodium phosphonoformate, a new antiviral compound
Science.
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Abstract
Trisodium phosphonoformate selectively inhibits cell-free DNA polymerase activity induced by herpesvirus. The new inhibitor has an antiviral effect on herpes simplex virus types 1 and 2, pseudorables virus, and infectious bovine rhinotracheitis virus in cell culture. It has a good therapeutic activity against cutaneous herpes simplex virus infection in guinea pigs.
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