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. 1978 Sep 1;201(4358):819-21.
doi: 10.1126/science.210500.

Trisodium phosphonoformate, a new antiviral compound

E Helgstrand, B Eriksson, N G Johansson, B Lannerö, A Larsson, A Misiorny, J O Norén, B Sjöberg, K Stenberg, G Stening, S Stridh, B Oberg

Trisodium phosphonoformate, a new antiviral compound

E Helgstrand et al. Science. .

Abstract

Trisodium phosphonoformate selectively inhibits cell-free DNA polymerase activity induced by herpesvirus. The new inhibitor has an antiviral effect on herpes simplex virus types 1 and 2, pseudorables virus, and infectious bovine rhinotracheitis virus in cell culture. It has a good therapeutic activity against cutaneous herpes simplex virus infection in guinea pigs.

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