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. 1990;79(3):227-34.
doi: 10.1007/BF01245133.

G-proteins (Gi, Go) in the basal ganglia of control and schizophrenic brain

F Okada  1 , T J Crow, G W Roberts
Affiliations

G-proteins (Gi, Go) in the basal ganglia of control and schizophrenic brain

F Okada et al. J Neural Transm Gen Sect. 1990.

Abstract

We detected the existence of Gi (the inhibitory G-protein) or Go (a similar G-protein of unknown function) in the striatum of control and schizophrenic brains utilizing pertussis toxin-catalyzed ADP ribosylation. The level of Gi/Go was significantly decreased by 42% in the putamen of the left hemisphere in schizophrenics; caudate head and globus pallidus levels were unchanged. Decreased Gi or Go may underlie enhanced dopamine function in the schizophrenic brain.

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