FNAIT: the fetus pleads guilty!
- PMID: 21051565
- DOI: 10.1182/blood-2010-08-299404
FNAIT: the fetus pleads guilty!
Abstract
Fetal/neonatal alloimmune thrombocytopenia (FNAIT) resulting from fetal platelet destruction by maternal alloantibodies is the most common cause of severe fetal thrombocytopenia and of neonatal thrombocytopenia in maternity wards. The pathophysiology is largely unknown. The fetus has long been considered as an "innocent bystander."
Comment on
-
Animal model of fetal and neonatal immune thrombocytopenia: role of neonatal Fc receptor in the pathogenesis and therapy.Blood. 2010 Nov 4;116(18):3660-8. doi: 10.1182/blood-2010-05-284919. Epub 2010 Jul 20. Blood. 2010. PMID: 20647570
Similar articles
-
Adding to the complexity of fetal and neonatal alloimmune thrombocytopenia: Reduced fibrinogen binding in the presence of anti-HPA-1a antibody and hypo-responsive neonatal platelets.Thromb Res. 2018 Feb;162:69-76. doi: 10.1016/j.thromres.2017.12.017. Epub 2017 Dec 29. Thromb Res. 2018. PMID: 29306729
-
Predicting risk severity and response of fetal neonatal alloimmune thrombocytopenia.Br J Haematol. 2013 Aug;162(3):304-12. doi: 10.1111/bjh.12372. Epub 2013 May 14. Br J Haematol. 2013. PMID: 23672281 Review.
-
Epidemiology and management of fetal and neonatal alloimmune thrombocytopenia.Transfus Apher Sci. 2020 Feb;59(1):102704. doi: 10.1016/j.transci.2019.102704. Epub 2019 Dec 31. Transfus Apher Sci. 2020. PMID: 31974030 Review.
-
Fetal and neonatal alloimmune thrombocytopenia.Semin Fetal Neonatal Med. 2016 Feb;21(1):19-27. doi: 10.1016/j.siny.2015.12.004. Epub 2016 Jan 20. Semin Fetal Neonatal Med. 2016. PMID: 26810319 Review.
-
Co-stimulation with LPS or Poly I:C markedly enhances the anti-platelet immune response and severity of fetal and neonatal alloimmune thrombocytopenia.Thromb Haemost. 2013 Dec;110(6):1250-8. doi: 10.1160/TH13-04-0354. Epub 2013 Sep 26. Thromb Haemost. 2013. PMID: 24067944
Cited by
-
Crosstalk between Platelets and the Immune System: Old Systems with New Discoveries.Adv Hematol. 2012;2012:384685. doi: 10.1155/2012/384685. Epub 2012 Sep 12. Adv Hematol. 2012. PMID: 23008717 Free PMC article.
Publication types
LinkOut - more resources
Full Text Sources