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. 2010 Nov;16(11):1218-22.
doi: 10.1038/nm.2221. Epub 2010 Sep 21.

Biomarkers in Alzheimer's disease drug development

Kaj Blennow  1
Affiliations

Biomarkers in Alzheimer's disease drug development

Kaj Blennow. Nat Med. 2010 Nov.

Abstract

Biomarkers may be of great value in Alzheimer's disease drug development to select the most optimal drug candidates for large and expensive phase 3 clinical trials. Biomarkers will also be important to provide evidence that a drug affects the underlying pathophysiology of the disease, which, together with a beneficial effect on the clinical course, will be essential for labeling the drug as having a disease-modifying effect.

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