doi: 10.1155/2010/605163.
Epub 2010 Oct 31.
The possible role of epigenetics in gestational diabetes: cause, consequence, or both
Affiliations
- PMID: 21052542
- PMCID: PMC2968420
- DOI: 10.1155/2010/605163
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The possible role of epigenetics in gestational diabetes: cause, consequence, or both
Obstet Gynecol Int.
2010.
Abstract
Gestational diabetes mellitus (GDM) is defined as the glucose intolerance that is not present or recognized prior to pregnancy. Several risk factors of GDM depend on environmental factors that are thought to regulate the genome through epigenetic mechanisms. Thus, epigenetic regulation could be involved in the development of GDM. In addition, the adverse intrauterine environment in patients with GDM could also have a negative impact on the establishment of the epigenomes of the offspring.
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References
-
- Marchetti P, Dotta F, Lauro D, Purrello F. An overview of pancreatic beta-cell defects in human type 2 diabetes: implications for treatment. Regulatory Peptides. 2008;146(1–3):4–11. - PubMed
-
- Campbell RK. Fate of the beta-cell in the pathophysiology of type 2 diabetes. Journal of the American Pharmacists Association. 2009;49:S10–S15. - PubMed
-
- Reece EA. The fetal and maternal consequences of gestational diabetes mellitus. J Matern Fetal Neonatal Med. 2010;23(3):199–203. - PubMed
-
- Ben-Haroush A, Yogev Y, Hod M. Epidemiology of gestational diabetes mellitus and its association with type 2 diabetes. Diabetic Medicine. 2004;21(2):103–113. - PubMed
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