doi: 10.1126/science.2105528.
Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif
Affiliations
- PMID: 2105528
- DOI: 10.1126/science.2105528
Item in Clipboard
Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif
Science.
.
Abstract
Activity of the immunoglobulin heavy and kappa light chain gene enhancers depends on a complex interplay of ubiquitous and developmentally regulated proteins. Two complementary DNAs were isolated that encode proteins, denoted ITF-1 and ITF-2, that are expressed in a variety of cell types and bind the microE5/kappa 2 motif found in both heavy and kappa light chain enhancers. The complementary DNAs are the products of distinct genes, yet both ITF-1 and ITF-2 are structurally and functionally similar. The two proteins interact with one another through their putative helix-loop-helix motifs and each possesses a distinct domain that dictates transcription activation.
Similar articles
-
Modulation of the IgH enhancer's cell type specificity through a genetic switch.Genes Dev. 1991 Jan;5(1):29-37. doi: 10.1101/gad.5.1.29. Genes Dev. 1991. PMID: 1899229
-
A developmentally modulated chromatin structure at the mouse immunoglobulin kappa 3' enhancer.Mol Cell Biol. 1996 Jun;16(6):3138-55. doi: 10.1128/MCB.16.6.3138. Mol Cell Biol. 1996. PMID: 8649425 Free PMC article.
-
Selective synergy of immunoglobulin enhancer elements in B-cell development: a characteristic of kappa light chain enhancers, but not heavy chain enhancers.Nucleic Acids Res. 1994 Oct 11;22(20):4216-23. doi: 10.1093/nar/22.20.4216. Nucleic Acids Res. 1994. PMID: 7937148 Free PMC article.
-
Combinatorial regulation of transcription II: The immunoglobulin mu heavy chain gene.Immunity. 1995 May;2(5):427-38. doi: 10.1016/1074-7613(95)90024-1. Immunity. 1995. PMID: 7749979 Review. No abstract available.
-
Helix-loop-helix proteins in the regulation of immunoglobulin gene transcription.Immunol Today. 1992 Jan;13(1):31-6. doi: 10.1016/0167-5699(92)90201-h. Immunol Today. 1992. PMID: 1739428 Review.
Cited by
-
Myocardial activation of the human cardiac alpha-actin promoter by helix-loop-helix proteins.Proc Natl Acad Sci U S A. 1992 May 1;89(9):4047-51. doi: 10.1073/pnas.89.9.4047. Proc Natl Acad Sci U S A. 1992. PMID: 1570331 Free PMC article.
-
Helix-loop-helix transcriptional activators bind to a sequence in glucocorticoid response elements of retrovirus enhancers.J Virol. 1991 Nov;65(11):6084-93. doi: 10.1128/JVI.65.11.6084-6093.1991. J Virol. 1991. PMID: 1681116 Free PMC article.
-
HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors.Mol Cell Biol. 1992 Mar;12(3):1031-42. doi: 10.1128/mcb.12.3.1031-1042.1992. Mol Cell Biol. 1992. PMID: 1312219 Free PMC article.
-
Characterization of the human immunoglobulin kappa gene 3' enhancer: functional importance of three motifs that demonstrate B-cell-specific in vivo footprints.Mol Cell Biol. 1992 Nov;12(11):5206-16. doi: 10.1128/mcb.12.11.5206-5216.1992. Mol Cell Biol. 1992. PMID: 1406692 Free PMC article.
-
HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human neuroblastoma.Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8492-6. doi: 10.1073/pnas.89.18.8492. Proc Natl Acad Sci U S A. 1992. PMID: 1528853 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
