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. 2011 Feb;91(2):e33-6.
doi: 10.1016/j.diabres.2010.10.003. Epub 2010 Nov 4.

Men with hyperferritinemia and diabetes in the Mediterranean area do not have a higher iron overload than those without diabetes

Núria Freixenet  1 , Carme Vilardell, Gemma Llauradó, Olga Giménez-Palop, Eugenio Berlanga, Cristina Gutiérrez, Assumpta Caixàs, Joan Vendrell, José Miguel González-Clemente
Affiliations

Men with hyperferritinemia and diabetes in the Mediterranean area do not have a higher iron overload than those without diabetes

Núria Freixenet et al. Diabetes Res Clin Pract. 2011 Feb.

Abstract

Aim: To assess the role of iron overload in type 2 diabetic men with hyperferritinemia.

Methods: 150 men were recruited from a genetic screening programme for hereditary hemocromatosis (HH) and were tested for type 2 diabetes, other components of the metabolic syndrome, beta cell function (BCF), insulin sensitivity, high-sensitivity C-reactive protein and iron overload.

Results: Fifty-one men had type 2 diabetes. They were older (p=0.017) and 99 had lower BCF (p<0.001) than non-diabetic men. None of the iron overload indexes was associated with diabetes.

Conclusions: Our findings dispute a role of iron overload in the pathogenesis of type 2 diabetes.

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