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. 2011 Jan;77(1):363-6.
doi: 10.1128/AEM.01675-10. Epub 2010 Nov 5.

Inactivation of Ascaris suum by short-chain fatty acids

Michael A Butkus  1 , Kelly T Hughes, Dwight D Bowman, Janice L Liotta, Michael B Jenkins, Michael P Labare
Affiliations

Inactivation of Ascaris suum by short-chain fatty acids

Michael A Butkus et al. Appl Environ Microbiol. 2011 Jan.

Abstract

Ascaris suum eggs were inactivated in distilled water and digested sludge by butanoic, pentanoic, and hexanoic acids. The fatty acids (short-chain fatty acids [SCFA]) were effective only when protonated and at sufficient concentrations. The conjugate bases were not effective at the concentrations evaluated. Predictions from an inhibition model (50% inhibitory concentration [IC(50)]) based on quantitative structure-activity relationships were congruent with inactivation data.

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Figures

FIG. 1.
FIG. 1.
Model of Ascaris suum inhibition (IC50, moles/liter) as a function of pH. Model predictions were based on a quantitative structure-activity model (QSAR) according to a relationship reported by Kamlet et al. (18).
FIG. 2.
FIG. 2.
(A) An Ascaris suum egg exposed to SCFA and exhibiting morphological damage to the interior cells. (B) A healthy A. suum egg.
See this image and copyright information in PMC

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