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. 2010 Dec;28(12):1300-3.
doi: 10.1038/nbt.1696. Epub 2010 Nov 7.

Rapid translocation of nanoparticles from the lung airspaces to the body

Hak Soo Choi  1 , Yoshitomo Ashitate, Jeong Heon Lee, Soon Hee Kim, Aya Matsui, Numpon Insin, Moungi G Bawendi, Manuela Semmler-Behnke, John V Frangioni, Akira Tsuda
Affiliations

Rapid translocation of nanoparticles from the lung airspaces to the body

Hak Soo Choi et al. Nat Biotechnol. 2010 Dec.

Abstract

Nano-size particles show promise for pulmonary drug delivery, yet their behavior after deposition in the lung remains poorly understood. In this study, a series of near-infrared (NIR) fluorescent nanoparticles were systematically varied in chemical composition, shape, size and surface charge, and their biodistribution and elimination were quantified in rat models after lung instillation. We demonstrate that nanoparticles with hydrodynamic diameter (HD) less than ≈34 nm and a noncationic surface charge translocate rapidly from the lung to mediastinal lymph nodes. Nanoparticles of HD < 6 nm can traffic rapidly from the lungs to lymph nodes and the bloodstream, and then be subsequently cleared by the kidneys. We discuss the importance of these findings for drug delivery, air pollution and carcinogenesis.

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Comment in

  • Nanoparticles in the lung.
    Kreyling WG, Hirn S, Schleh C. Kreyling WG, et al. Nat Biotechnol. 2010 Dec;28(12):1275-6. doi: 10.1038/nbt.1735. Nat Biotechnol. 2010. PMID: 21139613 No abstract available.

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References

    1. Janib SM, Moses AS, Mackay JA. Imaging and drug delivery using theranostic nanoparticles. Adv Drug Deliv Rev. 2010 - PMC - PubMed
    1. Zrazhevskiy P, Sena M, Gao X. Designing multifunctional quantum dots for bioimaging, detection, and drug delivery. Chem Soc Rev. 2010 - PMC - PubMed
    1. Choi HS, Frangioni JV. Nanoparticles for biomedical imaging: Fundamentals of clinical translation. Mol Imaging. 2010 in Press. - PMC - PubMed
    1. Courrier HM, Butz N, Vandamme TF. Pulmonary drug delivery systems: recent developments and prospects. Crit Rev Ther Drug Carrier Syst. 2002;19:425–498. - PubMed
    1. Tsuda A, Rogers RA, Hydon PE, Butler JP. Chaotic mixing deep in the lung. Proc Natl Acad Sci U S A. 2002;99:10173–10178. - PMC - PubMed

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