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. 2011 Jan;25(1):77-83.
doi: 10.1038/eye.2010.156. Epub 2010 Nov 5.

Combined trabeculotomy and trabeculectomy: outcome for primary congenital glaucoma in a West African population

V A Essuman  1 , I Z Braimah, T A Ndanu, C T Ntim-Amponsah
Affiliations

Combined trabeculotomy and trabeculectomy: outcome for primary congenital glaucoma in a West African population

V A Essuman et al. Eye (Lond). 2011 Jan.

Abstract

Purpose: To evaluate the surgical outcome of combined trabeculotomy-trabeculectomy in Ghanaian children with primary congenital glaucoma.

Materials and methods: A retrospective case series involving 19 eyes of 12 consecutive children with primary congenital glaucoma who had primary trabeculotomy-trabeculectomy from 12 August 2004 to 30 June 2008, at the Korle-Bu Teaching Hospital, Ghana. Main outcome measures were preoperative and postoperative intraocular pressures, corneal diameter, corneal clarity, bleb characteristics, duration of follow-up, surgical success, and complications.

Results: A total of 19 eyes of 12 patients met the inclusion criteria. Six of the patients were males. Mean age at diagnosis was 4.4 (range 2-8) months. Mean age at surgery was 5.9 months (range 3-16). Eight (67%) infants had bilateral disease. Mean duration of follow-up was 13.1 (range 5-38) months. The preoperative mean horizontal corneal diameter was 13.4 ± 1.1(range 12-16) mm. Complete success (intraocular pressure <21 mm Hg) was obtained in 15 (79%) eyes. The probability of success was 94.4, 83.3, 66.7, 44.4, 38.9, 33.3, and 13.3% at 3, 6, 9, 12, 15, 18, and 21 months, respectively (Kaplan-Meier analysis). All eyes had corneal oedema preoperatively. Seventeen eyes (90%) had clear cornea at their last follow-up. Mean preoperative and postoperative intraocular pressures were 30.3 ± 8.8 and 18.1 ± 6.8 mm Hg respectively (P<0.001, t-test). Twelve (63%) eyes had well-functioning blebs at the last follow-up. One eye (5%) developed seclusio pupillae and cataract postoperatively.

Conclusion: The overall success for combined trabeculotomy-trabeculectomy in Ghanaian children with primary congenital glaucoma was 79%. The probability of success reduced from more than 66% in the first 9 months postoperatively to below 45% after that.

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Figures

Figure 1
Figure 1
Effect of surgery on corneal clarity in 19 eyes with congenital glaucoma (preoperative eyes, n=18). Gd, grading of corneal clarity; n, number.
Figure 2
Figure 2
Kaplan–Meier curve showing the complete success probabilities in 19 eyes. n, number of eyes followed up.
Figure 3
Figure 3
(a) Preoperative photograph of a 10-week-old girl. (b) Photograph of the same girl, 24 months postoperatively.
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