Review
doi: 10.1002/bmc.1548.
Epub 2010 Nov 5.
Derivatization reagents in liquid chromatography/electrospray ionization tandem mass spectrometry
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- PMID: 21058414
- DOI: 10.1002/bmc.1548
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Review
Derivatization reagents in liquid chromatography/electrospray ionization tandem mass spectrometry
Biomed Chromatogr.
2011 Jan.
Abstract
Liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) is one of the most prominent analytical techniques owing to its inherent selectivity and sensitivity. In LC/ESI-MS/MS, chemical derivatization is often used to enhance the detection sensitivity. Derivatization improves the chromatographic separation, and enhances the mass spectrometric ionization efficiency and MS/MS detectability. In this review, an overview of the derivatization reagents which have been applied to LC/ESI-MS/MS is presented, focusing on the applications to low molecular weight compounds.
2010 John Wiley & Sons, Ltd.
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