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. 2010 Nov;67(11):1379-85.
doi: 10.1001/archneurol.2010.280.

Functional impact of white matter hyperintensities in cognitively normal elderly subjects

Melissa E Murray  1 , Matthew L Senjem, Ronald C Petersen, John H Hollman, Greg M Preboske, Stephen D Weigand, David S Knopman, Tanis J Ferman, Dennis W Dickson, Clifford R Jack Jr
Affiliations

Functional impact of white matter hyperintensities in cognitively normal elderly subjects

Melissa E Murray et al. Arch Neurol. 2010 Nov.

Abstract

Objective: To investigate the impact white matter hyperintensities (WMH) detected on magnetic resonance imaging have on motor dysfunction and cognitive impairment in elderly subjects without dementia.

Design: Cross-sectional study.

Setting: Population-based study on the incidence and prevalence of cognitive impairment in Olmsted County, Minnesota.

Participants: A total of 148 elderly subjects (65 men) without dementia ranging in age from 73 to 91 years.

Main outcome measures: We measured the percentage of the total white matter volume classified as WMH in a priori-defined brain regions (ie, frontal, temporal, parietal, occipital, periventricular, or subcortical). Motor impairment was evaluated qualitatively using the Unified Parkinson's Disease Rating Scale summary measures of motor skills and quantitatively using a digitized portable walkway system. Four cognitive domains were evaluated using z scores of memory, language, executive function, and visuospatial reasoning.

Results: A higher WMH proportion in all regions except the occipital lobe was associated with lower executive function z score (P value <.01). A higher WMH proportion in all regions, but most strongly for the parietal lobe, correlated with higher Unified Parkinson's Disease Rating Scale gait, posture, and postural stability sum (P value <.01). A higher WMH proportion, whether periventricular, subcortical, or lobar, correlated with reduced velocity (P value <.001).

Conclusions: We conclude that executive function is the primary cognitive domain affected by WMH burden. The data suggest that WMH in the parietal lobe are chiefly responsible for reduced balance and postural support compared with the other 3 lobes and may alter integration of sensory information via parietal lobe dysfunction in the aging brain. Parietal white matter changes were not the predominant correlate with motor speed, lending evidence to a global involvement of neural networks in gait velocity.

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Figures

Figure 1
Figure 1
A regional white matter (WM) atlas was created on our standard template and used to parcellate right/left periventricular (PV), subcortical (SC) and lobar WM hyperintensity volumes in subject space to compensate for inter-subject variation. Four representative slices can be found above proceeding from the inferior (top left) to superior (bottom right) direction. (Key: 1-SC frontal, 2-PV frontal, 3-SC temporal, 4-PV temporal, 5-SC parietal, 6-PV parietal, 7-SC occipital, not shown-PV occipital)
Figure 2
Figure 2
The plots along the top row depict the strength of the correlation that total, periventricular and subcortical WMHp have with clinical measures of cognition and motor skills. The bottom four plots are between the WMHp of the four main lobes of the brain and the clinical measures of cognition and motor skills.
See this image and copyright information in PMC

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